AGS – Aglycon sapogenins: Effective Natural Anti-cancer agent



Monday, August 29, 2011

What is it?

Aglycon Sapogenins (Dammarane Sapogenins) are extraordinarily effective anti-neoplastic (cancer fighting) substances.

What does it do?
The well known herb Panax ginseng, contains many substances called ginsenosides, which chemically are glycosides. Each ginsenoside contains a sugar and a non-sugar component. The non-sugar component is called an Aglycon Sapogenin (AGS)or Dammarane Sapogenin. There are many different kinds of these Aglycon Sapogenins, but the kind designated by the letter “R” have some remarkable properties. Once in the body they are broken down into Protopanaxadiol (PPD) and Protopanaxatriol (PPT.) There is also a metabolite called M1.

It turns out that these particular Aglycon Sapogenins are extraordinarily effective anti-neoplastic (cancer fighting) substances. Ginseng itself has no such property, probably because these substances are not concentrated enough in Ginseng root. Ginseng itself is fairly expensive but it takes 100 pounds of ginseng to get just 1 gram (a 30th of an ounce) of Algycon Ginsenoside. Some glycon ginsenosides actually promote tumor growth so they must be removed.

Among the benefits of Algycon Sapogenin are:

1. Near zero toxicity.

2. Effective against multiple drug resistant (MDR) cancers for which there is no treatment. The problem with cancers is as they multiply they mutate continuously. Many different genotypes may exist in one tumor and a drug may address only certain genotypes. The mutants are also selected to be resistant to the chemotherapy drug. AGS induces cancer cell death (apoptosis) by multiple pathways. AGS can reverse multiple drug resistance by inhibiting P-gp protein.

3. Enhances the therapeutic index of presently available chemotherapy drugs (i.e. Paclitaxel or mitoxanthrone) from between 1,000 to 20,000 times MDR Associated Chemosensitivity Enhancement (MACE).

4.Broad anticancer effectiveness on a wide range of cancer tissues (i.e. Glioblastoma SF 120, Prostate Cancer LNCaP, Breast Cancer MCF7, Melanoma B 16, Gastric Cancer KATO III, Lung Carcinoma H460 & H838.) In vitro (test tube) studies showed cytotoxicity to all cancer cell lines with zero survival at 40 micromolar concentration.

5. Crosses the blood brain barrier for effective treatment of brain cancer. In vitro animal implanted animal studies showed more than 45% survival at 45 days vs 0% for the controls after 18 days.

6. Attacks only cancer cells with no harm to normal cells. Among its effects on cancer cells is to arrest proliferation at the G1 stage. Induce cancer cells into benign differentiation. Decrease the rate of carcinogen formation by suppressing the functions of the P450 enzyme system. Competing with the estrogen receptor and inhibiting cell growth from estrogen stimulation.

One naturopathic doctor started using it in 1999 on 15 cancer patients who had not responded to other therapy. He says that 13 of them are still alive.

Another M.D. treating 15 patients with end stage cancer says that 85% are enjoying a good quality of life with diminished pain and more energy.

Another doctor who invented the protocol is following pancreatic cancer patients who typically live only 40 to 90 days after diagnosis. He says all are alive and enjoying a surprisingly good quality of life several months later.

Drug companies are working on a patentable version of this plant extract (one is called PBD-2131) but it is likely going to be the usual long process before it gains approval. The natural version works now.

For more information see Dammarane Sapogenins.

Examples of products:

Careseng BFG

Careseng SG2

Quite extensive research appears to have been carried out in China although there does not appear to be any scientific human trials carried out.

Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

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